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Table 2 Clinical characteristics of TCGA HPV(+) cohort by NSD1 mutation status

From: NSD1 mutations by HPV status in head and neck cancer: differences in survival and response to DNA-damaging agents

 

Mutant NSD1, n = 6

Wild-type NSD1, n = 59

p-value*

n

%

n

%

 

Avg. age at diagnosis (years)

51.8

 

57.8

 

0.15

Sex

    

0.41

 Female

0

0.0

6

10.2

 

 Male

6

100.0

53

89.8

 

Race

    

0.57

 Black or African American

0

0.0

3

5.1

 

 White

6

100.0

56

94.9

 

Smoking History Category

    

0.53

 Never Smoker

3

50.0

18

30.5

 

 Current Smoker

0

0.0

14

23.7

 

 Former Smoker

3

50.0

26

44.1

 

 Unknown

0

0.0

1

1.7

 

Alcohol Use

    

0.90

 No

1

16.7

13

22.0

 

 Yes

5

83.3

45

76.3

 

 Unknown

0

0.0

1

1.7

 

Stagea

    

0.65

 Stage I, II

1

16.7

11

18.6

 

 Stage III

0

0.0

7

11.9

 

 Stage IV

5

83.3

41

69.5

 
  1. *p-value is calculated from chi-square test for categorical variables or Wilcoxon rank-sum test for age (continuous)
  2. aStages assigned using AJCC 7th edition (63%), 6th edition (37%)
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Cancers of the Head & Neck

ISSN: 2059-7347

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