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  1. The optimal treatment for regional lymphatic recurrences from head and neck cancer has not been fully established. In order to explore the therapeutic benefit of surgical resection and adjuvant brachytherapy, ...

    Authors: Nayel Khan, Mark Clemens, Jun Liu, Adam S. Garden, Anne Lawyer, Randal Weber, G. Brandon Gunn, William H. Morrison and Michael E. Kupferman

    Citation: Cancers of the Head & Neck 2019 4:4

    Content type: Research

    Published on:

  2. Compared to HPV-negative head and neck squamous cell carcinomas (HNSCCs), HPV-positive HNSCCs are associated with a favorable prognosis in part due to their improved treatment sensitivity. Inactivating mutatio...

    Authors: Cassie Pan, Said Izreig, Wendell G. Yarbrough and Natalia Issaeva

    Citation: Cancers of the Head & Neck 2019 4:3

    Content type: Research

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  3. Patients with head and neck cancer (HNC) experience significant physical and psychological distress, which have a negative impact on their quality of life (QOL). Few strategies have been studied to help improv...

    Authors: Jordan J. Senchak, Carolyn Y. Fang and Jessica R. Bauman

    Citation: Cancers of the Head & Neck 2019 4:2

    Content type: Review

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  4. Human papillomavirus-associated oropharyngeal cancer (HPV-OSCC) is rapidly increasing in incidence and has unique epidemiologic, molecular, and biologic characteristics. Standard combined modality therapies fo...

    Authors: Panagiota Economopoulou and Amanda Psyrri

    Citation: Cancers of the Head & Neck 2019 4:1

    Content type: Commentary

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  5. Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papillom...

    Authors: Cassie Pan, Natalia Issaeva and Wendell G. Yarbrough

    Citation: Cancers of the Head & Neck 2018 3:12

    Content type: Review

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  6. Increased treatment package time is an independent poor prognostic factor for outcomes in head and neck squamous cell carcinoma (HNSCC). Similarly the timeliness of treatment initiation is a risk factor for di...

    Authors: Muhammad M. Fareed and Thomas J. Galloway

    Citation: Cancers of the Head & Neck 2018 3:11

    Content type: Review

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  7. Information on patients with differentiated thyroid carcinoma in South Africa is limited. The objective of this study was to review demographics and tumour characteristics in a cohort of patients with differen...

    Authors: B. Robertson, M. Parker, L. Shepherd, E. Panieri, L. Cairncross, F. Malherbe, IL. Ross, F. Omar and A. Hunter

    Citation: Cancers of the Head & Neck 2018 3:10

    Content type: Research

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  8. Despite improvements in diagnosis and patient management, survival and prognostic factors of patients with oral squamous cell carcinoma (OSCC) remains largely unknown in most of Sub Saharan Africa.

    Authors: Juliet Asio, Adriane Kamulegeya and Cecily Banura

    Citation: Cancers of the Head & Neck 2018 3:9

    Content type: Research

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  9. HPV related OPSCC has a distinct behavior and improved outcome. As immunotherapy has recently evolved into a new standard for advanced (SCCHN), trials for high-risk SCCHN have trended to encompass both HPV rel...

    Authors: Nabil F Saba, Shuli Li, Zain A Hussain, Rathan Subramanian, Joseph A Califano and Christine H Chung

    Citation: Cancers of the Head & Neck 2018 3:8

    Content type: Editorial

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  10. Airline crew are exposed to ionizing radiation as part of their occupation and have a documented increased risk of melanoma and cataracts. However, whether their occupation predisposes them to an increased ris...

    Authors: George S. Liu, Austin Cook, Michael Richardson, Daniel Vail, F. Christopher Holsinger and Ingrid Oakley-Girvan

    Citation: Cancers of the Head & Neck 2018 3:7

    Content type: Research

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  11. Significant weight loss and malnutrition are common in patients with head and neck cancer, despite advances in treatment and development of evidenced-based guidelines. The aim of this study was to assess adher...

    Authors: Sophie Hofto, Jessica Abbott, James E. Jackson and Elisabeth Isenring

    Citation: Cancers of the Head & Neck 2018 3:6

    Content type: Research

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  12. Extracapsular extension (ECE) is a well-established prognostic feature in squamous cell cancers of the head and neck. Although some extrapolate data from mucosal head and neck cancer to include ECE as a high-r...

    Authors: Shayan Cheraghlou, Phoebe K. Yu, Michael D. Otremba, Saral Mehra, Wendell G. Yarbrough and Benjamin L. Judson

    Citation: Cancers of the Head & Neck 2018 3:5

    Content type: Research

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  13. Human papilloma virus (HPV)-associated head and neck cancer is now recognized as a distinct clinical entity from HPV-negative tumors, which are primarily associated with tobacco and alcohol exposure.Little is...

    Authors: Hong Li, Henry S. Park, Heather A. Osborn and Benjamin L. Judson

    Citation: Cancers of the Head & Neck 2018 3:4

    Content type: Research

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  14. Circulating interleukin-6 (IL-6) improves outcome prediction for second primary cancer (SPC) in head and neck cancer (HNC) patients. This study aimed to identify factors associated with IL-6 serum levels in HN...

    Authors: Sylvine Carrondo Cottin, Stéphane Turcotte, Pierre Douville, François Meyer and Isabelle Bairati

    Citation: Cancers of the Head & Neck 2018 3:1

    Content type: Research

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  15. Synchronous squamous cell carcinoma of the head and neck (HNSCC) and non-Hodgkin’s lymphoma is a rare clinical scenario. It is unknown whether the R-CHOP chemotherapy for lymphoma would also be active against ...

    Authors: Ting Martin Ma, Hyunseok Kang, Steven P. Rowe and Ana P. Kiess

    Citation: Cancers of the Head & Neck 2018 3:2

    Content type: Case report

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  16. The present study evaluated clinical outcomes for patients with head and neck squamous cell carcinoma presenting with N3 nodal disease.

    Authors: Matthew E. Witek, Aaron M. Wieland, Shuai Chen, Tabassum A. Kennedy, Craig R. Hullett, Evan Liang, Gregory K. Hartig, Randy J. Kimple and Paul M. Harari

    Citation: Cancers of the Head & Neck 2017 2:8

    Content type: Research

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  17. Treatment modalities of head and neck squamous cell cancer include surgery, radiation, chemotherapy, targeted agents and immune checkpoint inhibition. Treatment is often toxic and can affect long-term function...

    Authors: Nnamdi Eze, Ying-Chun Lo and Barbara Burtness

    Citation: Cancers of the Head & Neck 2017 2:6

    Content type: Review

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  18. Transoral endoscopic head and neck surgery (eHNS), including transoral laser microsurgery (TLM) and transoral robotic surgery (TORS), provides access to subsites in the head and neck that have traditionally be...

    Authors: David W. Schoppy, Michael E. Kupferman, Amy C. Hessel, Diana M. Bell, Elizabeth M. Garland, Edward J. Damrose and F. Christopher Holsinger

    Citation: Cancers of the Head & Neck 2017 2:5

    Content type: Research

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  19. To find out how chemotherapy given prior to concurrent chemoradiotherapy compares with concurrent chemoradiation alone in the treatment of locally advanced nasopharyngeal cancer.

    Authors: Joel Yarney, Naa A. Aryeetey, Alice Mensah, Emmanuel D. Kitcher, Verna Vanderpuye, Charles Aidoo and Kenneth Baidoo

    Citation: Cancers of the Head & Neck 2017 2:4

    Content type: Research

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  20. Small cell carcinoma (SCC) is a rare variant of head and neck cancer characterized by a high-grade neuroendocrine cancer with similar features to small cell lung carcinoma (SCLC). Human papillomavirus (HPV) is...

    Authors: Marcelo Bonomi, Tamjeed Ahmed, David Warner, Joshua Waltonen, Christopher Sullivan, Mercedes Porosnicu, Katharine Batt, Jimmy Ruiz and James Cappellari

    Citation: Cancers of the Head & Neck 2017 2:3

    Content type: Case report

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  21. Locally advanced (stage III or IV) squamous cell carcinoma of the head and neck (SCCHN) often requires multimodal treatment, consisting of a combination of surgery, radiation, and/or systemic therapy, namely c...

    Authors: Paolo Bossi and Francesca Platini

    Citation: Cancers of the Head & Neck 2017 2:2

    Content type: Review

    Published on:

  22. Thyroid cancer incidence is rapidly increasing due to increased detection and diagnosis of indolent thyroid cancer, i.e. cancer that is likely to be clinically insignificant. Clinical, radiologic, and patholog...

    Authors: Lewis D. Hahn, Christian A. Kunder, Michelle M. Chen, Lisa A. Orloff and Terry S. Desser

    Citation: Cancers of the Head & Neck 2017 2:1

    Content type: Review

    Published on:

  23. Oropharyngeal cancer is frequently associated with human papilloma virus, that also represents a strong prognostic factor. Local relaps and treatment-related complications are frequent, whereas distant metasta...

    Authors: Daris Ferrari, Carla Codecà, Giulia Viale, Barbara Bocci, Francesca Broggio, Francesca Crepaldi, Martina Violati, Andrea Luciani, Dario Bauer, Laura Moneghini, Gaetano Bulfamante and Paolo Foa

    Citation: Cancers of the Head & Neck 2016 1:16

    Content type: Case report

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  24. For complex reconstruction of osseous defects of the head and neck, three-dimensional (3D) computer planning has been available for over 20 years. However, despite its availability and recent refinements, it i...

    Authors: Diana N. Kirke, Randall P. Owen, Vincent Carrao, Brett A Miles and Jason I. Kass

    Citation: Cancers of the Head & Neck 2016 1:17

    Content type: Review

    Published on:

  25. Venous thromboembolism (VTE) is a major cause of perioperative morbidity and mortality. Historically, otolaryngology surgery has been seen as very low risk of VTE, given the relatively short procedures and hea...

    Authors: Faisal I. Ahmad and Daniel R. Clayburgh

    Citation: Cancers of the Head & Neck 2016 1:13

    Content type: Review

    Published on:

  26. Therapeutic improvements and epidemiologic changes in head and neck cancer (HNC) over the last three decades have led to increased numbers of survivors, resulting in greater need for continuing management of o...

    Authors: Firoozeh Samim, Joel B. Epstein, Zachary S. Zumsteg, Allen S. Ho and Andrei Barasch

    Citation: Cancers of the Head & Neck 2016 1:14

    Content type: Review

    Published on:

  27. Head and neck squamous cell carcinoma (HNSCC) represents a model of escape from anti-tumor immunity. The high frequency of p53 tumor suppressor loss in HNSCC leads to genomic instability and immune stimulation...

    Authors: Ruth J. Davis, Robert L. Ferris and Nicole C. Schmitt

    Citation: Cancers of the Head & Neck 2016 1:12

    Content type: Review

    Published on:

  28. Germline CYLD mutation is associated with the development of a rare inheritable syndrome, called the CYLD cutaneous syndrome. Patients with this syndrome are distinctly presented with multiple tumors in the head ...

    Authors: Krista Roberta Verhoeft, Hoi Lam Ngan and Vivian Wai Yan Lui

    Citation: Cancers of the Head & Neck 2016 1:10

    Content type: Review

    Published on:

  29. Treatment of locally advanced squamous cell carcinomas of the head and neck (SCCHN) remains unsatisfactory. Although the addition of concurrent radiochemotherapy (RCT) or the combination of radiotherapy with b...

    Authors: Ingeborg Tinhofer, Volker Budach, Korinna Jöhrens and Ulrich Keilholz

    Citation: Cancers of the Head & Neck 2016 1:8

    Content type: Review

    Published on:

  30. The purpose of this study was to identify preoperative patient characteristics associated with the incidence of positive surgical margins or lymph node extracapsular extension (ECE), which necessitate adjuvant...

    Authors: Harry E. Subramanian, Henry S. Park, Andrea Barbieri, Amit Mahajan, Benjamin L. Judson, Saral Mehra, Wendell G. Yarbrough, Barbara A. Burtness and Zain A. Husain

    Citation: Cancers of the Head & Neck 2016 1:7

    Content type: Research

    Published on:

  31. The current treatment paradigm in head and neck cancer does not adequately address its clinical and biological heterogeneity. Data from genomic profiling studies in head and neck squamous cell carcinoma (HNSCC...

    Authors: Kyaw L. Aung and Lillian L. Siu

    Citation: Cancers of the Head & Neck 2016 1:2

    Content type: Review

    Published on:

  32. Human papillomavirus (HPV)-positive oropharyngeal cancer primarily affects working-age adults. Chemotherapy and radiation (CTRT) used to treat this disease may adversely impact a survivors’ ability to work aft...

    Authors: Shrujal S. Baxi, Talya Salz, Han Xiao, Coral L. Atoria, Alan Ho, Stephanie Smith-Marrone, Eric J. Sherman, Nancy Y. Lee, Elena B. Elkin and David G. Pfister

    Citation: Cancers of the Head & Neck 2016 1:4

    Content type: Research

    Published on:

  33. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers associated with prolonged exposure t...

    Authors: Tim N. Beck and Erica A. Golemis

    Citation: Cancers of the Head & Neck 2016 1:1

    Content type: Review

    Published on:

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