From: De-intensification of adjuvant therapy in human papillomavirus-associated oropharyngeal cancer
Extra Nodal Extension Grading System | ||
---|---|---|
Grade | Histologic Finding | ENE positivity |
0 | Tumor is surrounded by lymphoid tissue | – |
1 | Tumor reaches the capsule (with no intervening lymphoid tissue) with thickening of overlying capsule | – |
2 | Tumor in perinodal tissue, extending ≤ 1 mm beyond capsule | + |
3 | Tumor in perinodal tissue and extending > 1 mm beyond capsule | + |
4 | Tumor mass without residual nodal tissue or architecture. No residual lymphoid architecture or germinal center. | + |